Therefore, maintaining the correct levels of metal ions in the cytoplasm is essential for life and health.Īs we know, metal ions cannot directly penetrate the cell membrane unless the transporter’s assistance is on the cell membrane. Their homeostasis disorders involve neurodegenerative diseases, cardiovascular diseases, bone diseases, asthma, cancer, and diabetes. Also, other metal ions perform their respective biological functions. Zn 2+ is a multitasking tool necessary to stimulate various enzyme activities that lack and excess can cause central nervous system diseases. Mg 2+ regulates ion channels’ activity in cardiac cells, affecting the myocardium’s electrical properties. For example, Ca 2+ signaling is essential for T cell activation, autoantigen tolerance, differentiation, and development. They can enter cells to regulate the expression and activation of multiple biomolecules, participate in cell signal transduction, and complete various functions. Metal ions are vital to live organisms involving in various biological processes. This paper explores the interaction mechanism between TMPs and metal ions, which is helpful to understand the structure and function of TMPs and is of great significance to further construct transport mechanisms and identify potential drug targets.
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The results in the independent verification dataset show that TMP-MIBS has superior performance. Thereby, we compared our model with the published tools which do not distinguish TMPs from water-soluble proteins. At present, there is no specific research on the metal ion binding prediction of TMPs. To predict the metal ion binding sites for TMPs on a large scale, we present a simple and effective two-stage prediction method TMP-MIBS, to identify the corresponding binding residues using TMP sequences. Whether you want to transition from vinyl to CD or hard disk for DJ performance or you just want the flexibility and portability that only digital files can offer, LP 2 CD is an uncompromisingly high-quality transition tool.The metal ion binding of transmembrane proteins (TMPs) plays a fundamental role in biological processes, pharmaceutics, and medicine, but it is hard to extract enough TMP structures in experimental techniques to discover their binding mechanism comprehensively.
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